Programa Cientifico/Scientific Program (PDF)

16h45 – 17h30 | Opening Ceremony | Room A

17h30 – 17h45 | 50 years of the Annual Meeting on Basic Research in Chagas Disease | Room A

How it all began
Walter Colli (USP, São Paulo, Brazil)

17h45 – 18h30 | Opening Conference – Samuel Pessoa Award | Room A
Chair: Walter Colli

Fifteen Years Of A Successful Proposal: Trypanosoma Cruzi Strains Should Be Assigned To One Of The Discrete Typing Units
Bianca Zingales (USP – São Paulo – Brazil)

18h30 – 20h30 | Cocktail | GYMNASIUM

19h00 – 21h00 | Dinner

09h00 – 10h50 | Oral Presentations

OP.01 – Oral Presentations| ROOM A
Chairs: Sandra Maruyama and Paula Melo de Abreu Vieira

HP001 – The kinase IP6K plays a crucial role in DNA metabolism and infectivity in trypanosomatids
MARCELO S. DA SILVA

HP002 – The importance of the Tc?3GalT gene for the infectivity and intracellular development of Trypanosoma cruzi
CAROLINA MACEDO KOELLER

HP003 – Retinal microvascular alterations induced by acquired Toxoplasma gondii infection in C57BL/6 mice
VLADIMIR PEDRO PERALVA BORGES MARTINS

HP004 – A novel vaccine strategy for Chagas disease based on RNA containing sequences from Trypanosoma cruzi trans-sialidases
CARLOS ROBERTO DE ALMEIDA JÚNIOR

PV024 – Mitotic Spindle Kinase and New Mitotic Spindle Components Unveiled by Chemical Genetic Tools in Leishmania
JULIANA B. T. CARNIELLI

HP005 – The biological characterization of the Trypanosoma cruzi oligosaccharyltransferase (STT3)
LAYS ADRIANNE MENDONÇA TRAJANO SILVA

HP006 – Virtual Screening and Drug Repurposing in the Inhibition of Leishmania major Adenylosuccinate Lyase (LmASL)
MARIA EDUARDA SOUZA DIAS LINO

HP007 – Senescent cytotoxic CD4+ T cells cause skin pathology in human cutaneous leishmaniasis
DANIEL DE OLIVEIRA GOMES 

PV029 – LeishGEM: A genome-scale database for knockout mutant life cycle fitness phenotyping and subcellular protein localisation in Leishmania mexicana.
JEREMY C. MOTTRAM

OP.02 – Oral Presentations | ROOM B
Chairs: Daniel Lahr and Ana Paula Lima

HP008 – Identification of Chagas disease biomarkers using untargeted metabolomics
PAU BOSCH NICOLAU

HP009 – Endoplasmic reticulum stress affects the co-infection of Leishmania amazonensis and the phlebovirus (Pheniviridae) Icoaraci.
DANIEL MARCOS JÚLIO AGOSTINHO

HP010 – Eosinophils are an important modulator of parasitemia, cytokine balance and tissue damage during severe experimental malaria
LUIZA PINHEIRO SILVA

HP011 – Comprehensive Analysis of Nascent Transcriptome Reveals Diverse Transcriptional Profiles Across the Trypanosoma cruzi Genome.
PEDRO LEONARDO CARVALHO DE LIMA

HP012 – Golgi-localized TcNST3 from Trypanosoma cruzi imports GDP-mannose via an exchanger mechanism driven by luminal GMP and GDP
FLAVIA SOUZA MORINI

HP013 – Both Trypanosoma cruzi infection and T. cruzi-derived extracellular vesicles induce activation of the DNA damage response pathway in host cells
RAUL ALEXANDER GONZÁLES CÓRDOVA

TB001 – Targeting a unique mRNA decapping enzyme for trypanosomatid infectious disease drug discovery
MARTIN ZOLTNER

TB002 – Novel Oral Treatment Candidates for Visceral Leishmaniasis Identified Through Molecular Docking
JULIANA SIMONATO FERREIRA

OP.03 – Oral Presentations | ROOM C
Chairs: José Luciano Nepomuceno-Silva and Yara Traub-Cseko

PV001 – A role for Variant Surface Glycoprotein mRNA in driving allelic competition
DOUGLAS ESCRIVANI DE OLIVEIRA

PV002 – A novel comprehensive map of the trypanosome nuclear pore and a trypanosomatid-unique mechanism of nuclear export
BERNARDO PAPINI GABIATTI

PV003 – Expansion and validation of Trypanosoma cruzi genome-scale metabolic model iIS312 for the construction of a tool for metabolism in silico analysis and prediction
BRUNO RIBEIRO PINTO

PV004 – Ultrastructural Organization of Paratrypanosoma confusum revealed by CryoEM
CAROLINA DE LIMA ALCANTARA

PV005 – Glycosomal phosphoenolpyruvate carboxykinase disruption affects the metacyclogenesis and infectivity of Trypanosoma cruzi
CAROLINA SILVA DIAS VIEIRA

PV006 – Bioinformatics-driven identification of conserved satellite DNA motifs in Trypanosoma cruzi genomes for enhanced diagnostic targeting
NATHAN RAVI MEDEIROS HONORATO

PV007 – Studying translational machinery composition of Trypanosoma cruzi during metacyclogenesis and cell cycle by a multiomics approach
MARTÍN RIVARA

PV008 – A new recombinant chimeric antigen, derived from five antigenic proteins from Leishmania infantum, is highly efficient for the serodiagnosis of both human and canine Visceral Leishmaniasis
HEMILLY RAYANNE FERREIRA DA SILVA

PV009 – Expanding kinetoplastid genome annotation through protein structure comparison
JUAN TRINIDAD

10h30 – 11h00 | Coffee break

11h00 – 11h25 | Conferences 01 and 02

Conference 01 | ROOM A
Chair: Ariel Silber

TESEO Phase-2 Trial: Unveiling Safer, Effective Chemotherapies and Reliable Biomarkers of Cure for Chagas Disease
Igor Almeida (University of Texas at El Paso, USA)

Conference 02 | ROOM B
Chair: Pedro Lagerblad de Oliveira

Exploring the triatomine-trypanosome interactions.
Alessandra Guarneri (Fiocruz, Belo Horizonte, Brazil)

12h00 – 14h30 | Lunch

13h30 – 14h30 | SBPz Council Meeting

14h30 – 16h30 | Round-Tables

RT.01 – Metabolism and Mitochondria Biology of Trypanosomes | ROOM A
Chair: Ariel Silber

•A story of ageing and rejuvenation: mitochondrial DNA dynamics in trypanosomatid parasites
Achim Schnaufer (University of Edinburgh, UK)
• FoF1 ATP synthase dimers: what are they good for?
Alena Ziková (University of South Bohemia, Tchequia)
• Development of chemical tools to investigate Trypanosomes metabolism
Artur Cordeiro (LNBio – CNPEM, Brazil)
• Exploring Trypanosoma cruzi energy metabolism: a journey between mitochondrion and glycosomes
Marcia Paes (UERJ, Brazil)

RT.02 – Drugs for Neglected Diseases | ROOM B
Chair: Camila Indiani de Oliveira

• Pipeline of candidates for chagas disease – challenges in translational sciences
Jadel Kratz (DNDi-RJ, Brazil)
• Parasitology at the forefront: how T. cruzi biology is still driving and limiting drug discovery for Chagas disease
Carolina Borsoi Moraes (FCF-USP -SP, Brazil)
•Evaluation of therapeutic regimens for Chronic Chagas disease based on 2 weeks of benznidazole. Update and future perspectives
Israel Molina (Vall d’Hebron University, Spain)
• DNDI’s leishmaniasis portfolio: future perspective on oral treatments
Glaucia Cota (DNDi-RJ, Brazil)

16h30 – 17h00 | Coffee-Break

17h00 – 17h25 | Conferences 03 e 04

CO.03 – | ROOM A |
Chair: Wanderson Duarte da Rocha

The Ongoing Story of Leishmania/Phlebovirus Coinfection: From The Bench To Field Work In Brazil
Ulisses Gazos Lopes (UFRJ, Rio de Janeiro, Brazil)

CO.04 –  | ROOM B

Chair: Igor de Almeida

(Trypanasoma cruzi: a stealthy parasite seeking shelter from the storm) Bradykinin-induced Microvascular Leakage: A Dual Role for the Kallikrein-Kinin System in the Pathogenesis of Chagas Disease
Julio Scharfstein (UFRJ, Rio de Janeiro, Brazil)

17h25 – 17h50 |Conferences 05 e 06

CO.05 –  | ROOM A

Chair: Júlia P. Chagas da Cunha

Trypanosoma cruzi bioenergetics: using histidine to charge batteries
Ariel Silber (USP, São Paulo, Brazil)

CO.06 – |ROOM B
Chair: Elvira Saraiva

The biology of sexual mating in Leishmania
David Sacks (NIH Clinical Center, USA)

18h00 – 19h00 | SBPz Plenary – Ordinary General Assembly | ROOM B

19h00 – 20h30 | Dinner

20h30 – 22h00 | Poster Session – ODD | GYMNASIUM

09h00 – 11h00 | Round-Tables

RT.03 – Clinical Practice and Epidemiology of Chagas Disease | ROOM A
Chair: Renata Tonelli

•Hsp90 inhibitor-based formulation cures experimental cutaneous leishmaniasis by killing the parasite dependent on a direct mechanism
Patricia Veras (FIOCRUZ-BA, Brazil)
• Long-term follow up of the Natural History of Leishmania infantum infection in endemic visceral leishmaniasis area
Selma Jerônimo (UFRN, Brazil)
• Some remarks on reservoirs hosts of Leishmania (Viannia) braziliensis and the eco-epidemiology of cutaneous leishmaniasis in high endemicity area of Northeast Brazil
Sinval Brandão (Fiocruz-PE, Brazil)
• Chagas Disease a “new” clinical challenge
Fabio De Rose Ghilardi (USP, Brazil)

RT.04 – Early Career Researchers | ROOM B
Chair: Maria Fernanda Laranjeira

• CAMKII as a master regulator of T cruzi infection and the chagasic arrhythmogenic cardiomyopathy
Artur Miranda (UFMG, Brazil)
• Single-cell atlas of Leishmania major in the sand fly vector during development and transmission
Carolina Catta Preta (NIH, USA)
• Leishmania braziliensis PRMT5: effects on the transcriptome of metacyclic forms and on amastigogenesis
Gustavo Campagnaro (USP, Brazil)
•Cell Cycle Dynamics During Metacyclogenesis in Trypanosoma cruzi: Protein Expression and G1 Arrest.
Simone Guedes Calderano (Butantan Institute, Brazil)

11h00 – 11h30 | Coffee break

11h30 – 11h55 | Conferences 07 and 08

Conference 07 | ROOM A
Chair: Angela Hampshire

Mitochondrial functions and calcium signaling im T. Cruzi
Anibal Vercesi (Unicamp, Brazil)

Conference 08 | ROOM B
Chair: Osvaldo Pompilio de Melo Neto

Post-transcriptional regulation in Kinetoplastids: how did we get here and where do we go next?
Christine Clayton (Heidelberg University, Germany)

12h30 – 14h10 | Lunch

14h10 – 16h10 | Round-Tables

RT.05 – Toxoplasma gondii: Invasion, metabolism, Treatment and Outcomes | ROOM A
Chair: Daniel Adesse

• Recent advances on Neuro-Vascular abnormalities in experimental Toxoplasmosis
Daniel Adesse (FIOCRUZ-IOC-RJ, Brazil)
•Decoding the Toxoplasmosis-Schizophrenia Link: Insights from a Large-Scale Study on Infection, Symptom Severity, and Psychosis Onset
Letusa Albrecht (FioCruz, PR, Brazil)
• Insights from a novel culture system of Toxoplasma gondii cysts: Fats, Drugs and Targets
Martin Blume (Robert Koch-Institut, Germany)
• Regulating Turnover of The Toxoplasma Cytoskeleton and Invasion Machinery
Michael Reese (The University of Texas Southwestern, USA)

RT.06 – Vaccines for Parasitic Diseases | ROOM B
Chair: Herbert Guedes

•Central, Effector and Resident Memory Triggered By A Polyepitope Vaccine Associated With Poly-Iclc Adjuvant Plays An Important Role In The Response Against Experimental Visceral Leishmaniasis
Alexandre Reis (UFOP, Brazil) – CANCELED
• Role of Inflammasome in the Mechanism of Intranasal LaAg Vaccination
Herbert Guedes (UFRJ, Brazil)
• Rationally designed, prophylactic glycan- and peptide-based vaccines prevent cardiomyopathy in a nonhuman primate model of Chagas disease
Priscila S. G. Farani (UTEP, USA)
• Development of pan-Trypanosomatidae vaccines: proof of concept and updates
Ricardo Fujiwara (UFMG, Brazil)

16h10 – 16h40 | Coffee break

16h40 – 17h05 | Conferences 09 e 10

CO.09 – | ROOM A |
Chair: Santuza M. Teixeira

Single cell analysis of RNA expression in Trypanosoma cruzi
Sergio Schenckman (UNIFESP, São Paulo, Brazil)

CO.10 –  | ROOM B
Chair: Ana Bahia

Cyclical transmission of Trypanosoma brucei in the tsetse fly depends on two distinct RNA-binding proteins
Álvaro A. Serrano (University of Notre Dame, USA)

17h05 – 19h05 | Round-Tables

RT.07 – RNA processing and editing | ROOM A
Chair: Otavio H. Thiemann and Daniel Lahr

• Insights into the translation machinery and RancRNAs of T. cruzi.
José Sotelo (Universidad de la Republica, Uruguay)
• Mitochondrial RNA helicases of Trypanosomes
Inna Afasizhev (Boston University, USA)
• Mitochondrial RNA editing machines of Kinetoplastea
Ruslan Afasizhev (Boston University, USA)

RT.08 – Host-Parasite Interaction | ROOM B
Chair: Anderson Guimarães-Costa

•Neutrophil Extracellular Vesicles: Modulators of the Immune Response and Leishmania Infection
Anderson Guimarães-Costa (UFRJ, Brazil)
• Immunological mechanisms and ultrastructural changes in alternative treatments for toxoplasmosis at maternal-fetal interface: an update
Bellisa Barbosa (UFU, Brazil)
• Old Cells, New Functions: Emerging Insights into Senescent T Cells in American Tegumentary Leishmaniasis Skin Pathology
Daniel Gomes (UFES, Brazil)
• Toxoplasma gondii-induced Neutrophil Extracellular Traps: Current Insights and Future Directions
Rafael Mariante (Fiocruz-RJ, Brazil)

19h05 – 19h30 | Conferences 11 e 12

CO.11 – | ROOM A |
Chair: Ulisses G. Lopes

From Trypanosoma cruzi & neglected tropical diseases to SARS-CoV-2 & pandemics: Challenges and perspectives of yesterday and today
Carlos Morel (Fiocruz-RJ, Brazil)

CO.12 – | ROOM A |
Chair: Renata R. Tonelli

Exploring the Contribution of DNA Replication to the Evolutionary Dynamics of Trypanosma cruzi Genomic Compartments
Maria Carolina Elias (Butantan Institute, São Paulo, Brazil)

19h30 – 20h30 | Dinner

20h30 – 22h00 | Poster Session – EVEN | GYMNASIUM

09h00 – 11h00 | Round-Tables

RT.09 – Cell Biology | ROOM A
Chair: Marcia Attias and Narcisa Cunha-e-Silva

• Leishmania infantum Infection Enhances Human Dendritic Cell Migration in 2D and 3D Environments: Implications for Disease Visceralization?
Juliana Perrone Fullam (FIOCRUZ-BA, Brazil)
•Search for Leishmania factors that contribute to parasite entry and survival in the macrophage
Beatriz Stolf (USP, Brazil)
• Surface proteins in Acanthamoeba castellanii and their relationship with energy metabolism and host-parasite interaction
Luiz Fernando Carvalho-Kelly (UFRJ, Brazil)
• New views of Toxoplasma gondii in the feline host
Marcia Attias (UFRJ, Brazil)
• Exploring the Old and the New of the Osmoregulatory System of Trypanosoma cruzi Through Cryo-EM
Ingrid Augusto (UFRJ, Brazil)

RT.10 – Protozoan-Insect Interaction | ROOM B
Chair: Yara Traub-Cseko

• Bacillus sp. isolated from Triatoma sordida enhances Trypanosoma cruzi development
Ana Bahia, (UFRJ, Brazil)
• Digestion in triatomines and interactions with trypanosomatids: new findings and perspectives
Fernando Genta, (Fiocruz-RJ, Brazil)
• Patients undergoing therapy for malaria have the ability to transmit Plasmodium vivax to mosquito vectors within the initial days of treatment
Paulo Pimenta (Fiocruz-MG, Brazil)
• Uncovering the secrets of vector competence focusing on two Amazonian sand fly populations from leishmaniasis endemic and non-endemic areas.
Yara Traub-Cseko (Fiocruz-RJ, Brazil)

11h00 – 11h30 | Coffee break

11h30 – 11h55 | Conferences 13 and 14

Conference 13 | ROOM A
Chair: Sergio Schenkman

TRYPANOSOMA CRUZI: A STORY OF 50 YEARS AT CAXAMBU AND THE IMPACT TO BRAZILIAN SCIENCE
Samuel Goldenberg (FIOCRUZ, Curitiba, Brazil)

Conference 14 | ROOM B
Chair: Camila Indiani de Oliveira

Hypoxia and cutaneous leishmaniasis
Fernanda Novais (The Ohio State University, USA)

12h30 – 14h30 | Lunch

14h30 – 16h30 | Round-Tables

RT.11 – Tribute to Prof Erney Camargo | ROOM A
Chair: Carolina Catta-Preta

• Erney Plessmann Camargo, A trail blazer: One Health and Trees
Jeffrey J. Shaw (USP, Brazil)
• There and back again: completing decade-long puzzles with a true master
João Marcelo Alves (USP, Brazil)
• Few words to a great man
Lucile Maria Floeter Winter (USP, Brazil)

RT.12 – Science Communication | ROOM B
Chair: Eduardo Caio Torres dos Santos

• Initiatives of scientific dissemination
  Cristiana Ferreira Alves de Brito (Instituto René Rachou, FIOCRUZ MG, Brazil)
• Edutainment as a tool for disseminating scientific knowledge
  Kátia Cristina Pereira Oliveira Santos (UNIFESP, Brazil)
• The potential of digital platforms in bridging gaps between Academia and Society: an example of a Citizen Science project
  Lucio Freitas Junior (USP, Brazil)
• CHAGAS EXPRESS XXI: Active search for diagnosis and treatment of chronic Chagas disease in integrated surveillance and health care actions in vulnerable territories covered by the Healthy Brazil Program
  Tânia Araújo Jorge (Instituto Oswaldo Cruz, FIOCRUZ RJ, Brazil)
• The Discovery of Chagas Disease to Scale: From the Castle to the Train in Lassance
  Luiz Andrade

16h30 – 17h00 | Coffee-Break

17h00 – 17h40 | Closing Conference | ROOM A
Chair: Jeffrey Shaw

Genomics and biology of Trypanosoma rangeli, a non-virulent trypanosome of mammals
Edmundo Grisard (UFSC – Florianópolis, SC – Brazil)

17h40 – 18h10 | Closing Cerimony, Remarks and Awards | ROOM A

19h00 – 20h30 | Dinner